Clinical Management Issues 2019-03-26T16:34:24+00:00 Laura Fascio Pecetto Open Journal Systems <p>eISSN 2283-3137</p><p> </p><p><em>Clinical Management Issues</em> publishes mainly <strong>case reports and articles on clinical management of a disease</strong> in all the fields of medicine and is published by <a href="" target="_blank">SE<em>Ed</em> Medical Publishers</a>.</p><p><em>Clinical Management Issues</em><em> </em>is available and indexed in:</p><ul><li><a href=";publication=Clinical+Management+Issues" target="_blank">Crossref</a></li><li><a href="" target="_blank">DOAJ</a></li><li><a href="" target="_blank">EMCare</a></li><li><a href="" target="_blank">Emerging Sources Citation Index</a> (ESCI)</li><li><a href="" target="_blank">OpenAIRE</a></li><li><a href=";sourceid=21218&amp;la=en&amp;fIDnum=|&amp;mode=simple" target="_blank">SHERPA/RoMEO</a></li></ul><p><em>Clinical Management Issues</em> is an <a href="/index.php/cmi/about/editorialPolicies#custom-0">open access</a> journal. The aim is to provide clinical content of the highest quality, authority and accessibility.</p><p>The aim of the published case reports is to expand medical knowledge, allowing a better explanation of the practical application of a clinical guideline, or including an up-to-date review of medical knowledge in that field, or helping doctors to make better decisions in a “grey area”, or explaining how to manage a disease with an integrated approach between different specialists involved.</p><p><em><strong>Clinical Management Issues </strong></em>also publishes unusual case reports (i.e. unusual side effects or adverse interactions involving medications, unexpected or unusual presentations of a disease, etc.), <span>articles on clinical management of a disease, case series, editorials, and brief reports.</span></p><p>Content is subject to <a href="/index.php/cmi/about/editorialPolicies#peerReviewProcess">peer-review</a> and is editorially independent. This journal provides immediate open access to all of its articles (both HTML and PDF versions) on the principle that making research freely available to the public supports a greater global exchange of knowledge. Authors are asked to state any professional and financial situations that might be perceived as causing a conflict of interest with respect to integrity of content.</p><p>Submitted articles should follow the <a title="Author Guidelines" href="/index.php/cmi/about/submissions#authorGuidelines" target="_blank">author guidelines</a>.</p> A Case of Paroxysmal Nocturnal Hemoglobinuria (PNH) in an Obstetric Patient: A South African Perspective 2019-03-26T16:34:24+00:00 Garrick Laudin Lizemarie Wium <p class="abstract">Paroxysmal Nocturnal Hemoglobinuria (PNH) originates from an acquired genetic defect in a multipotent hematopoietic stem cell that becomes stem-cell-like in its ability to survive, expand, and self-renew. PNH is a rare condition characterized by intravascular hemolysis. PNH can arise anew or in the setting of an underlying bone marrow disorder such as aplastic anemia (AA), myelodysplastic syndrome (MDS), or primary myelofibrosis (PMF).</p><p class="abstract">This case presentation documents the challenging diagnosis of PNH in the obstetric setting, in which other possible causes for a hemolytic anemia could be considered. We discuss the management of a pregnancy in the presence of PNH in a low-to-middle income setting.</p><p> </p> 2019-01-16T10:11:02+00:00 Copyright (c) 2018 Atypical Presentation of Periodic Paralysis: A Case Report 2019-03-26T16:34:01+00:00 Aysun Isiklar <p class="abstract">Hypokalemic periodic paralysis (HPP) is a kind of periodic paralysis, which is a heterogeneous group of muscle diseases. It is characterized by episodes of flaccid and sudden muscle weakness.</p><p class="abstract">Here, we present a case of HPP. The patient was referred to our department because of severe dizziness and fall. After a comprehensive evaluation, a markedly low potassium was detected. The patient’s symptoms resolved after replacement of potassium and he was discharged without deficits. Even though the literature reports an association with exercise, carbohydrate load, and stress, further workup in our patient revealed no association with these precipitants. A proper differential diagnosis should rule out other causes of weakness and paralysis, thus allowing a timely treatment.</p> 2019-02-04T10:55:38+00:00 Copyright (c) 2019