Clinical Management Issues <p>eISSN 2283-3137</p><p> </p><p><em>Clinical Management Issues</em> publishes mainly <strong>case reports and articles on clinical management of a disease</strong> in all the fields of medicine and is published by <a href="" target="_blank">SE<em>Ed</em> Medical Publishers</a>.</p><p><em>Clinical Management Issues</em><em> </em>is available and indexed in:</p><ul><li><a href=";publication=Clinical+Management+Issues" target="_blank">Crossref</a></li><li><a href="" target="_blank">DOAJ</a></li><li><a href="" target="_blank">EMCare</a></li><li><a href="" target="_blank">Emerging Sources Citation Index</a> (ESCI)</li><li><a href="" target="_blank">OpenAIRE</a></li><li><a href=";sourceid=21218&amp;la=en&amp;fIDnum=|&amp;mode=simple" target="_blank">SHERPA/RoMEO</a></li></ul><p><em>Clinical Management Issues</em> is an <a href="/index.php/cmi/about/editorialPolicies#custom-0">open access</a> journal. The aim is to provide clinical content of the highest quality, authority and accessibility.</p><p>The aim of the published case reports is to expand medical knowledge, allowing a better explanation of the practical application of a clinical guideline, or including an up-to-date review of medical knowledge in that field, or helping doctors to make better decisions in a “grey area”, or explaining how to manage a disease with an integrated approach between different specialists involved.</p><p><em><strong>Clinical Management Issues </strong></em>also publishes unusual case reports (i.e. unusual side effects or adverse interactions involving medications, unexpected or unusual presentations of a disease, etc.), <span>articles on clinical management of a disease, case series, editorials, and brief reports.</span></p><p>Content is subject to <a href="/index.php/cmi/about/editorialPolicies#peerReviewProcess">peer-review</a> and is editorially independent. This journal provides immediate open access to all of its articles (both HTML and PDF versions) on the principle that making research freely available to the public supports a greater global exchange of knowledge. Authors are asked to state any professional and financial situations that might be perceived as causing a conflict of interest with respect to integrity of content.</p><p>Submitted articles should follow the <a title="Author Guidelines" href="/index.php/cmi/about/submissions#authorGuidelines" target="_blank">author guidelines</a>.</p> SEEd en-US Clinical Management Issues 1973-4832 Authors who publish with this journal agree to the following terms:<br /><ol type="a"><ol type="a"><li>Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a <a href="" target="_blank">Creative Commons Attribution Non-Commercial 4.0 Licence</a> that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.</li><li>Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. The Publication Agreement can be downloaded <a title="Publishing Agreement" href="/index.php/cmi/manager/files/repository/Publishing_Agreement_CMI.pdf" target="_blank">here</a>, and should be signed by the Authors and sent to the Publisher when the article has been accepted for publication in this journal.</li><li>Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See <a href="" target="_blank">The Effect of Open Access</a>).</li><li>Authors are permitted to post their work online after publication (the article must link to publisher version, in html format)</li></ol></ol> A Case of Paroxysmal Nocturnal Hemoglobinuria (PNH) in an Obstetric Patient: A South African Perspective <p class="abstract">Paroxysmal Nocturnal Hemoglobinuria (PNH) originates from an acquired genetic defect in a multipotent hematopoietic stem cell that becomes stem-cell-like in its ability to survive, expand, and self-renew. PNH is a rare condition characterized by intravascular hemolysis. PNH can arise anew or in the setting of an underlying bone marrow disorder such as aplastic anemia (AA), myelodysplastic syndrome (MDS), or primary myelofibrosis (PMF).</p><p class="abstract">This case presentation documents the challenging diagnosis of PNH in the obstetric setting, in which other possible causes for a hemolytic anemia could be considered. We discuss the management of a pregnancy in the presence of PNH in a low-to-middle income setting.</p><p> </p> Garrick Laudin Lizemarie Wium Copyright (c) 2018 2019-01-16 2019-01-16 13 1 10.7175/cmi.v13i1.1392 Atypical Presentation of Periodic Paralysis: A Case Report <p class="abstract">Hypokalemic periodic paralysis (HPP) is a kind of periodic paralysis, which is a heterogeneous group of muscle diseases. It is characterized by episodes of flaccid and sudden muscle weakness.</p><p class="abstract">Here, we present a case of HPP. The patient was referred to our department because of severe dizziness and fall. After a comprehensive evaluation, a markedly low potassium was detected. The patient’s symptoms resolved after replacement of potassium and he was discharged without deficits. Even though the literature reports an association with exercise, carbohydrate load, and stress, further workup in our patient revealed no association with these precipitants. A proper differential diagnosis should rule out other causes of weakness and paralysis, thus allowing a timely treatment.</p> Aysun Isiklar Copyright (c) 2019 2019-02-04 2019-02-04 13 1 10.7175/cmi.v13i1.1383